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If these symptoms persist, providers may recommend maintaining therapy at the previously tolerated dose while they investigate the potential for underlying issues

doi: 10.1046/j.1365-2133.1999.02780.x

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While Nrf2 and JAK2/STAT3 are indeed activated as protective responses during MIRI, the overwhelming and dynamic nature of the oxidative insult often impairs their full protective capacity or overwhelms the defense mechanisms they regulate, leading to a functional failure in restoring redox balance