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Transl Psychiatry 12(1):194 Ckaa M, Strosznajder JB (2010) The role of cyclooxygenases in neurotoxicity of amyloid peptides in Alzheimers disease

The role of oxidative stress in the COVID-19 disease may involve recognition of the viral S-protein by angiotensin converting enzyme-2 (ACE2) receptor and pattern recognition receptors like toll-like receptors 2 and 4, and activation of transcription factors like nuclear factor kappa B, that subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) expression succeeded by ROS production (Kozlov et al., 2021)

And yet I found myself rooting for the unenhanced athletes

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While they are normally the result of stress, free radicals can be caused by other environmental factors like smoke and pollutants