The significance of this paper is not only to compare the three routes of administration but also to evaluate them and determine which route is the best to administrate the drug
Hear from Diana Isaacs, PharmD, BCACP, BC-ADM, CDCES and Natalie Bellini, DNP, BC-ADM, CDCES about findings from the ATTAIN-1 trial of orforglipron for obesity in this episode of Diabetes Dialogue
Senescent cells are cells that have permanently halted their cell cycle ('replicative arrest') but resist apoptosissometimes called 'zombie cells.' They accumulate with age in multiple tissues and secrete a pro-inflammatory cocktail called the Senescence-Associated Secretory Phenotype (SASP), containing IL-6, IL-8, MMP-3, MMP-9, TNF-, and other factors that damage surrounding healthy tissue
And maybe, potentially, whether that also leads to more productivity and days of work
A diverse, healthy microbiome = more GLP-1-stimulating SCFAs