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Studied doses typically range from 900 to 1,500 mg daily, divided into two or three doses to minimize gastrointestinal side effects, though it's important to note that berberine has poor and variable oral bioavailability

Nozue T, Fukui K, Takamura T, Sozu T, Hibi K, Kishi S, Michishita I (2017) Effects of alogliptin on fractional flow reserve evaluated by coronary computed tomography angiography in patients with type 2 diabetes: Rationale and design of the TRACT study

Kumar DS, Deivasigamani K, Roy B