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Several enzymes involved in the glutathione pathway, such as -glutamylcysteine synthetase (GCLC), glutathione synthetase (GSS), glutathione peroxidase 4 (GPX4), and glutathione reductase (GSR), are regulated, at least in part, by Nrf2 through its activation of the Nrf2-antioxidant response element

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The total NADH/NAD + ( c ) and NADPH/NADP + ( d ) ratios measured in HeLa cells expressing Ec STH and mito Ec STH incubated for 24 hours at 5%CO 2 /1%O 2 hypoxia

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