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One important distinction: some early clinical observations noted rare cases of thrombotic events in specific patient subgroups, particularly those with existing clotting disorders or recent surgeries

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These oxidized lipids give rise to over expression of adhesion molecules and secretion of pro-inflammatory cytokines that promote generation of fatty streaks made of T cells and foam cells loaded with lipids (Namazi, Shomali, Taghikhani, & Nazifi, 2018)

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However, any pre-existing thyroid conditionincluding hyperthyroidismrequires careful evaluation before starting therapy