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In a sodium iodate (SIO)-induced RPE cell model, oxidative stress suppresses the expression of FSP1 while depleting intracellular reduced CoQ 10 and reduced nicotinamide adenine dinucleotide (NADH), ultimately triggering lipid peroxidation cascades and leading to RPE cell death

Published preclinical research describes a range of experimental doses used in animal models

Am J Clin Nutr 89: 71-76.