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13 Less common but important side effects include: Gallstones (rare) Kidney problems, especially in older adults who already have kidney disease Significant weight loss, which could be concerning for frail elderly people Special considerations for older adults: Stomach problems can lead to dehydration, which can be more serious in older adults

It plays a central role in developing antibiotic resistance, thus increasing the bacterial adaptability [48]

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doi:10.1016/j.tplants.2004.01.006

Adems, la aplicacin semanal es una ventaja relacionada a la adherencia al tratamiento y calidad de vida por la disminucin de los pinchazos