Committee members were asked to evaluate BPC-157, which is thought to promote tissue repair, for ulcerative colitis
As a protease inhibitor, A2M reduces inflammation in arthritic joints and helps to deactivate a variety of proteinases that typically degrade joint cartilage
This disrupts disc structure, reduces mechanical integrity, and impairs cell-matrix interactions necessary for regeneration
Many users find this dose sufficient for significant improvement
the FDA has stated it lacks sufficient information to know whether the substance would cause harm when administered to humans Evidence snapshot: The evidence base is almost entirely preclinical, decades of animal (largely rat) studies, mostly from one Croatian research group (Sikiric et al., University of Zagreb), with a single small human trial under the brand name "Bepecin" (around 2015) that did not lead to any FDA-approved use