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J Exp Biol 203(12):17771782 Decker H, Schweikardt T, Nillius D, Salzbrunn U, Jaenicke E, Tuczek F (2007) Similar enzyme activation and catalysis in hemocyanins and tyrosinases

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The predicted binding mode places neuromedin C along the canonical peptide-binding groove, consistent with the class B1 GPCR two-domain recognition paradigm in which peptide ligands are initially oriented by extracellular receptor elements and subsequently stabilize the active TM architecture required for signaling (Figure 4)