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However, some patients undergoing TRT may experience elevated blood pressure as a side effect

These proteins, acting as cyclin-dependent kinase (Cdk) inhibitors, lead to the arrest of the G1 phase, and activation of the senescence pathway [90]

Statements Author contributions ZZ: Conceptualization, Visualization, Writing original draft, Writing review & editing

DMT1 is a key protein regulating iron balance, and DMT1 inhibitors have been reported to selectively target CSCs in primary cancer cells and circulating cancer cells, causing ferroptosis in breast cancer CSCs and reversing multidrug resistance through lysosomal iron accumulation and ROS production

Glutaminase 2 (GLS2) participates in glutamine metabolism