BC and JY performed the experiments, analyzed the data, and prepared the manuscript
Activated mutant FGFR3 (aFGFR3) upregulates the expression of key SSP enzymes such as PHGDH and PSAT1 through downstream signaling pathways, promoting intracellular de novo serine synthesis in bladder cancer cells ( Specifically, elevated serine synthesis subsequently activates the PI3K/Akt pathway in tumor-associated macrophages, shifting macrophages toward an immune-inert phenotype
Marleen J, De Vree L, Jacquemin E, Cresteil D, Bosma PJ, Aten J, Deleuze J-F, Desrochers M, Burdelski M, Bernard O, et al
doi: 10.1038/onc.2016.252 92 LiuYCaoX
The results of the analyses of these samples are presented in the following sections