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Semaglutide (Wegovy, approved June 2021) and tirzepatide (Zepbound, approved November 2023) represent the current standard of care for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity [7][8]

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For FOXO4-DRI, this modification is essential because it allows the therapeutic peptide to persist long enough in vivo to reach and enter senescent cells