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How Retatrutide May Work How Triple Agonist Weight Loss Research Works Retatrutide is being studied because it combines three metabolic pathways that may work together: In phase 3 clinical trials, Lilly is evaluating Retatrutide across several obesity and weight-related health conditions, including obesity, overweight with weight-related medical problems, type 2 diabetes, sleep apnea, knee osteoarthritis, cardiovascular and renal outcomes, and liver-related metabolic disease

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The exact mechanisms remain under investigation, but the data suggest that higher doses (especially over 1,000mg per week) and longer durations of use may significantly increase the risk of adverse cardiovascular effects (Baggish et al, 2017, Pope et al, 2014)

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