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Some individuals may experience mild side effects such as insomnia, changes in taste, nausea, or mood swings

doi: 10.3390/ijms221910325 [DOI] [PMC free article] [PubMed] [Google Scholar] 7

It is crucial to consider the research design and follow-up period when evaluating the results because large-scale clinical trials, such as the LEADER trial, have not continuously indicated an increased cancer risk [44]

PMID 15102946

Also, the adverse cardiovascular safety in clinical trials before 2008 was evaluated based on populations that were not necessarily at high risk of cardiovascular disease and the follow-up duration was relatively short (usually less than 12 months)