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While immune activation can effectively clear damaged mitochondria (Harding et al., 2023), immune dysfunction has been reported to trigger mitochondrial impairments and thereby increase the oxidative damage within the cell (Tresse et al., 2021)

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Among emerging pharmacological approaches, GLP-1 receptor antagonists, SGLT1 inhibitors , somatostatin analogs , and other drug class which helps in stabilizing glycemic variability and reducing recurrent hypoglycemic episodes in PBH patients