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Hepatic inflammation is evaluated by the extent of lymphocyte infiltration and production of inflammatory cytokines and chemokines, which are often induced by transcription factor NF-B (Mihm et al., 2004

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Accordingly, several in vitro , pre-clinical and clinical studies have reported low immunogenicity, anti-inflammatory, anti-bacterial, anti-oxidative, and anti-scarring properties of placental-derived materials in different skin wound healing models, and 28 decellularized or devitalized placental matrices are currently FDA approved for clinical use as wound dressings (Moore et al., 2015