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This pattern suggests GHK-Cu provided temporary stimulation rather than inducing self-sustaining structural changes, requiring continuous or cyclical application for maintaining optimal results

It is a 53-amino-acid polypeptide weighing roughly 6,200 Daltons, which immediately makes it too large to cross intact stratum corneum at meaningful concentrations

Potential Implications: The peptides efficacy in healing gastrointestinal fistulas and anastomoses suggests potential therapeutic applications in related conditions

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Cecal levels of Akkermansia muciniphila have been strongly correlated with physiological metrics including glycemia and insulinemia 89 , and Akkermansia has correlated negatively with obesity-related measures 90 and has been implicated in DIO prevention 91,92