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Metformin can cause side effects such as gas, bloating, nausea, diarrhea, abdominal discomfort, and loss of appetite

Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP-1, NEJM 2021, n=1,961) Jastreboff AM et al

This helps restore cellular energy reserves and may reduce the severity of the metabolic crashes associated with exertion

This workup includes serum lactate dehydrogenase, chest radiograph, and combined positron emission tomography/computed tomography scanning of the chest, abdomen, and pelvis [16]

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