native glp-1 GLP-1-based therapies for diabetes, obesity and beyond Glucagon-like peptide-1 analogues: An overview

Jensen MD, Ryan DH, Apovian CM, et al

2025 Richard Weil, M.Ed., CDE, All Rights Reserved

The unexpected finding that exendin-4 has neuroprotective effects in animal models of various neurodegenerative diseases opens the door to testing this drug as a treatment for a number of devastating human diseases, such as Alzheimers. I think the fact that we have been able to take this substance found in nature and consider applying it in such incredibly diverse waysto treat diabetes, to possibly treat neurological diseaseadds to the growing body of support for a link between the endocrine and nervous systems, adds Dr

Chemical synthesis and subsequent in vivo evaluation of a GIP/GLP-1MK-801 co-agonist conjugate revealed enhanced weight loss in DIO mice compared with mice treated with the GIP/GLP-1 co-agonist alone (Extended Data Fig

But honestly