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Plaintiffs argue that manufacturers knew, or should have known, of the full scope of these risks based on c linical data , adverse event reports, and post-market surveillance, yet failed to provide clear, timely warnings to physicians and patients

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Therapeutic implications: context-specific applications The efficacy of antiangiogenic therapies is highly dependent on their application in the appropriate pathological contexts

Example 2 Medication only These patients usually have a BMI between 25 and 30 and do not need a meal replacement or a focused diet