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2 Further, there are no large, multicenter trials to evaluate safety, dosage, or long-term use of these compounds in athletes

We have strong data in discordant populations [4], [5]

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A comprehensive 2017 meta-analysis of 17 randomized controlled trials involving over 1,600 patients with chronic heart failure confirmed that targeted L-carnitine treatment significantly improves left ventricular ejection fraction and overall cardiac output