Unlabeled GLP-1(736)NH 2 or GLP-1(737) was added in concentrations ranging from (100 pM to 1 M), and subsequently [ 125 I]GLP-1(736)NH 2 (10.6 pM) was added, followed by 3 h of incubation at 4 C
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This study suggests that liraglutide may effectively reduce body weight and mitigate hyperphagia caused by MC4R deficiency, providing a basis for its potential therapeutic application in patients with MC4R -deficient obesity
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