The uptake of butyrate by colonocytes helps provide optimal colonising conditions for members of the intestinal microbiota which are predominantly obligate anaerobes
Underneath that effect is a cascade of metabolic, neurological, and cellular changes that researchers are still mapping, and those deeper pathways are almost certainly why some people lose dramatic amounts of weight while others on the same dose see much more modest results
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In a statement to Insider, Novo Nordisk, the company that makes Wegovy and Ozempic, said that Gila monsters and the discovery of exendin-4 "did not have anything to do with our decision to develop long-acting GLP-1 receptor agonists" for obesity, because "that was based on GLP-1 biology in humans." But the company also said that "the GLP-1-like effect of exendin-4" in Gila monsters was "an important contribution to the field," as it led to the development of the very first injectable drug of its kind
