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Preparation of nanoprobes Considering the pharmacodynamic concentrations of R848 and ILD as well as the low encapsulation rate of R848, we used ILD and R848 as the feeding ratio of 5:1 (m/m) to prepare the nanoprobe BEAGA/ApoE-PDHD@ILD & R848 29,47

MIC stands for methionine, inositol, and choline, three lipotropic compounds that help the body metabolize fat and remove it from the liver

For example, reduced glutathione helps regenerate vitamin E and vitamin C levels in the body

The study has been performed in accordance with the principles of Declaration of Helsinki