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Gastrointestinal tolerability of once-weekly semaglutide. Diabetes Therapy , 2022

and AUC for digoxin 0120 h after a single dose of digoxin

In the insulin regimen analysis, the proportion of patients with any on-treatment AE was somewhat higher in the patients receiving oral semaglutide added to basal-bolus insulin (8287%) than among those receiving oral semaglutide plus basal (6582%) or premixed (6980%) insulin, but no such trend was evident in the incidence of gastrointestinal or serious AEs, or in those leading to trial product discontinuation (see Table S2 in the Supplementary Information)

This is the most compelling long-term argument for establishing ketogenic eating habits while on semaglutide rather than simply using semaglutide as a passive appetite suppressant