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Because INCB024360 was well tolerated, it has the potential to be potent as either a monotherapy or part of combination therapy

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A finalized public record shows only the methods, fields, and results present for that named lot

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Thus, a potential mechanism underlying paclitaxel-induced chemobrain is the overactivation of intrasynaptic functions ( Similarly, paclitaxel affects synaptic plasticity by increasing presynaptic NMDA receptor (NMDAR) activity, especially that of GluN2A-containing subunits, in the spinal cord, thereby mediating neuropathic pain (Xu et al., 2022)