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Estrogen deficiency can also impact appetite regulation, according to animal studies that have linked decreased estrogen with increased hunger and a reduction in spontaneous physical activity

Our 2025 study in JMIR Formative Research examined 12-month outcomes for participants using semaglutide with behavioural support and found 1 : 19.1% average weight loss at 12 months for active subscribers 77.7% achieved at least 10% weight loss 61.5% achieved at least 15% weight loss 69% reported no side effects by month 12 These are completer results (people who stayed on the programme for 12 months), not intent-to-treat

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A consumer-advocacy approach means slowing down long enough to compare the full monthly picture before a checkout page makes the decision feel urgent