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Agmatine (decarboxylated L-arginine): physiological role and therapeutic potential

The anti-glycation effect is primarily attributed to decarboxy carnosine, which blocks AGE cross-linking reactions and protects target proteins from modification 23

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External resources New England Journal of Medicine: Retatrutide Phase 2 Trial for Obesity PMC: Comparative Efficacy of Tirzepatide vs Retatrutide Network Meta-Analysis Nature Medicine: Retatrutide for Metabolic Dysfunction-Associated Steatotic Liver Disease U.S

Among the activated compounds, only DPDPE displayed a clear concentration-dependent activation of human GLP-1R (Figure 5)