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Examples include: Wellbutrin, an antidepressant that can be used off-label for weight loss and smoking cessation Metformin, which is FDA approved to treat Type 2 diabetes and is also often used off-label for polycystic ovarian syndrome (PCOS) Contrave, a combination of Wellbutrin and naltrexone, a drug developed for the treatment of substance disorders Qsymia, a combination of the prescription weight loss drug phentermine and the anti-epilepsy drug Topamax (topiramate), which aids in weight loss when combined with a proper diet and exercise It may also decrease binge eating

Your optimal dose depends on how your body's GLP-1 receptors respond, your tolerance to side effects, and your weight loss objectives

You are 100% responsible for anything that enters your body

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The reason lies not in the molecule but in the dose and the indication