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Digestive symptoms are already the most common side effects associated with GLP-1-based medications, so combining two drugs with similar actions could intensify these effects

In ingestible form it is sold for gut healing or healing in general

To avoid this, physicians may elect to divert the small intestine outside of the abdomen, with the patient wearing a pouch to catch waste/stool (an ileostomy) rather than reconnecting the small intestine to the rectum

Moreover, some studies illustrated that some specific modifications of NP surface could mitigate the toxicity of NPs and make them tissue-specific (Lai et al., 2021)