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2024 Sep 18;9(1):234

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SURMOUNT-5 Trial Results This Phase 3b, open-label trial randomized 751 adults with obesity (but without diabetes) to receive either: Maximum tolerated dose of tirzepatide (10 mg or 15 mg) Maximum tolerated dose of semaglutide (1.7 mg or 2.4 mg) Key findings at 72 weeks: The trial concluded that tirzepatide was superior to semaglutide with respect to reduction in body weight and waist circumference at week 72