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FIGURE 8 Next, we used a highly potent NF-B inhibitor, BAY 11-7082, to further verify the role of NF-B pathway in SGNs damage induced by peroxynitrite (Figure 9)

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This aligns with findings from the STEP-2 25 and STEP-6 studies 25 , which reported higher incidences of psychiatric events with higher doses of semaglutide compared to placebo