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Nature (2015) 528(7581):2626.10.1038/nature15766 191 WuHEsteveETremaroliVKhanMTCaesarRManneras-HolmLet alMetformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

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They found that, at the beginning of the aggregation process, nearly all of Abeta-40s amides had access to free exchange, whereas only about 33 of the 41 amides available in Abeta-42 underwent exchange

The research dose that produced the documented 1.4-fold BDNF increase was 50 mcg/kg body weight administered intranasally