Inject slowly into a muscle or vein
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While IGF-I remains the biomarker that best reflects endogenous GH secretion, when there is a discordancy with GH and IGF-I levels, it is important for the clinician to be mindful of the associated changes in intra-portal insulin delivery to the liver when interpreting these results in the context of health and when deciding treatment regimens in disease states
Therefore, this study confirms our earlier findings that the pulsatile (as opposed to the tonic) component of GH secretion is the specific regulator of fat metabolism during prolonged starvation
For patients with uncontrolled hypothyroidism, thyroid hormone replacement should be optimized first, as untreated hypothyroidism can affect glucose metabolism and weight management outcomes
