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WO 00/53148 discloses and claims a "method for the treatment of erectile dysfunction which comprises administering to a human subject in need of such treatment an effective amount of an agonist of the melanocortin receptor in combination with an effective amount of a cyclic-GMP- specific phosphodiesterase inhibitor or an alpha-andrenergic receptor antagonist. MT-II is a disclosed melanocortin receptor agonist and sildenafil is a disclosed PDE-5 inhibitor

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The clinical translation of these trial results, which will be important for the comparison of GLP-1RAs with SGLT2 inhibitors in the treatment of patients with heart failure and a preserved ejection fraction, remains to be determined

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