In the SURMOUNT-1 trial, people treated with tirzepatide lost up to 22.5% of their body weight over 72 weeks , making it even more effective than semaglutide (NEJM tirzepatide study)
When symptoms occur, they usually relate to underlying conditionssuch as liver disease, kidney dysfunction, or haematological disordersthat cause the elevation
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Increased lean body mass: Some studies indicate it can increase lean body mass, but not necessarily strength or physical function
A 2021 Nature Communications study then showed that MOTS-c is induced by exercise and that treating mice, including animals started late in life, boosted running capacity and physical performance across young, middle-aged, and old groups [3]
