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doi: 10.1136/jim-2021-001952 23 MinTBainSC

The widespread marketing of curcumin as a nutritional supplement exists in tension with the therapeutic claims increasingly advanced for enhanced-bioavailability formulations intended for use in metabolic disease a tension that demands a correspondingly higher evidentiary standard, analogous to that applied to botanical pharmaceuticals in regulated markets

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This approach means side effects may be milder and shorter-lived than if you moved to high doses all at once