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Notably, all four genes map to pathways highlighted in the metabolomics analysis, indicating convergence between transcriptional and metabolic signals (Figure 4G)

Though its exact mechanism of action in the brain is still unidentified, lithium has been shown in the research to boost neurotransmitter activity, including that of dopamine and serotonin, and to reduce the activity of the excitatory brain chemical glutamate

In contrast, tirzepatide shows promising cardiovascular potential, but these effects are still under ongoing clinical research

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