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Aim for consistent fluid intake throughout the day

Abbreviations BDG: Bilirubin diglucuronide BMG: Bilirubin monoglucuronide BVRA: Biliverdin reductase A BVRB: Biliverdin reductase B NAFLD: Non-alcoholic fatty liver disease HMOX: Heme oxygenase HRG1: Heme-responsive gene-1 FNP-1: Ferroprotein ABCG5: ATP-binding cassette subfamily G member 5 ABCG8: ATP-binding cassette subfamily G member 8 BACH1: BTB and CNC homology 1 BLVR: Biliverdin reductase BVRA: Biliverdin reductase A BVRB: Biliverdin reductase B FNP1: Ferroportin 1 HMOX: Heme oxygenase HMOX1: Heme oxygenase 1 HMOX2: Heme oxygenase 2 HRG1: Heme-responsive gene 1 MRP2: Multidrug resistance-associated protein 2 NAFLD: Non-alcoholic fatty liver disease NRF2: Nuclear factor erythroid 2-related factor 2 UGT1A1 : UDP-glucuronosyltransferase 1A1 FXR: Farnesoid X receptor PXR: Pregnane X receptor CAR: Constitutive androstane receptor ASBT: Apical sodium-dependent bile acid transporter OATP: Organic anion transporting polypeptide TNF-: Tumour necrosis factor- alpha IL-1 : Interleukin-1 LSECs: Liver sinusoidal endothelial cells IBABP: Ileal bile acid-binding protein BSH: Bile salt hydrolase from bacteria FGF19/15 : Fibroblast growth factor 19/15 TGR5: G-protein-coupled bile acid receptor 1 SHP: Small heterodimer partner References Costa CJ, Nguyen MTT, Vaziri H, Wu GY (2024) Genetics of gallstone disease and their clinical significance: a narrative review

Zinc plays an important role in ammonia metabolism and its detoxification in the liver.24,25 Other factors that contribute to the development of HE are lactate and excess manganese.26 7 HE is characterized by neurologic, neuropsychiatric, and musculoskeletal alterations, whose clinical presentation is variable and heterogeneous

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Mitochondria are cholesterol-poor organelles compared to plasma membrane, and this regulated transport of cholesterol in mitochondria plays physiological role in the synthesis of bile acids in liver and steroidogenic hormones in other tissues