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These studies indicate that GLRs integrate biotic stress perception with systemic signalling, potentially coupling ionic responses to redox-sensitive secondary metabolites such as phenolics and flavonoids, which reinforce oxidative and structural defences

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Maquart, Pickart, and colleagues established this in fibroblast culture in 1988 ( FEBS Letters ) and confirmed it in vivo in rat wound models in 1993 ( Journal of Clinical Investigation ) 5 6

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