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As the disease progresses, retinal ischaemia triggers the release of vascular endothelial growth factor (VEGF), stimulating the growth of fragile new blood vessels (neovascularisation) characteristic of proliferative diabetic retinopathy

These findings highlight the importance of combining GLP-1 medications with proper nutrition and lifestyle habits, such as eating a protein-rich diet and incorporating regular resistance training to support skeletal muscle and metabolic health

Patients should not discontinue tirzepatide without discussing with their healthcare provider, as this may lead to deterioration in glycemic control or weight regain

Individuals with one copy of the variant lost an average of 0.76 kg more than those without it, and those with two copies lost 1.52 kg more

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