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JAMA 2019;321:146680.PubMedPMC 24

When taken together, these effects may be additive, potentially affecting treatment adherence and quality of life

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Weight loss recommendations may be particularly important for patients at highest risk for weight gain and cardiovascular morbidity, such as young/premenopausal patients, postmenopausal patients with estrogen receptorpositive disease on endocrine therapy, and/or preexisting cardiovascular disease risk factors

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