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Some common side effects include : Nausea Vomiting Constipation Diarrhea Reflux/heartburn Reduced enjoyment of food due to appetite suppression Although GLP-1s have been used in diabetes treatment for nearly two decades, there is still much to learn about the long-term impact of newer, more potent versions
Moreover, while GLP-1 analog therapy is clearly effective in regulating blood glucose of obese patients, the anorexic effects of the acute peripheral injections of GLP-1 or EX4 may be attenuated in rats fed a high-fat diet (Williams et al., 2011)
Novo said Lilly acknowledges the existence of that high-dose Wegovy in a "small footnote," but called it "ambiguous, confusing, virtually illegible, and wholly inadequate," as it does not communicate that it is significantly more effective than the lower doses of the drug