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55 A systemic review and meta-analysis of randomised clinical trials evaluating cardioprotective glucose-lowering medications also found that GLP-1 receptor agonists were associated with a significant reduction in dementia risk

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Lancet Diabetes Endocrinol 2021;9:212224 [DOI] [PubMed] [Google Scholar] 68

Staged initiation : Consider starting tirzepatide first, allowing 8-12 weeks for dose titration and gastrointestinal adaptation before adding creatine supplementation

This is the mechanism behind the prolonged fullness that GLP-1 drug users describe