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GA can enhance AMPK phosphorylation in a dose-dependent manner, inhibit the transcriptional activity of SREBP-1 and its downstream fatty acid synthase (FASN) and ACC to downregulate lipogenesis, thereby inhibiting hepatic lipogenesis and accumulation and reducing hepatic steatosis in fructose-induced NAFLD mice (Tanaka et al., 2020)

Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappaB pathways in traumatic brain injury in mice