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Low BDNF in the hippocampus and amygdala is associated with increased anxiety-like behavior in animal models, and human studies show reduced serum BDNF in patients with generalized anxiety disorder

Metformin is also protective against chemical-induced liver injury

They are not a compounding pharmacy, and they do not provide dosing or administration guidance

Consistent with earlier studies, our data confirm that treatment with ALC was remarkably well tolerated with no treatment-related serious adverse event requiring treatment interruption and/or patient withdrawal

Table 3 describes supplements for which there is relevant literature in ME/CFS