The landmark PANTHEON trial, a 1-year multicenter RCT in 1,006 Chinese COPD patients, found that high-dose NAC (600 mg twice daily) reduced the rate of acute exacerbations by 22% compared to placebo (1.16 vs 1.49 exacerbations per year, p=0.0011) (Zheng et al., Lancet Respir Med, 2014) [44]
Growth hormone depletion, along with hormone imbalances, are primary drivers of the aging process
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2018) demonstrated a significant increase in the GSH/GSSG ratio in the brain of patients with PD after NAC administration, indicating enhanced redox balance and reduced oxidative stress