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GLP-1 receptor agonists work by increasing the levels of the hormone GLP-1 in the body, which helps to increase the bodys sensitivity to insulin and reduce hunger

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However, as explained above, GLP-1Rs are not only localized to organs involved in the glycemic response, such as the pancreas and the liver, but are also expressed in various regions of the brain through neurons and glial cells [108]

Craving-related effects are not part of their approved safety profile