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Clinical guidelines currently recommend the use of hormonal drugs developed for contraception as first-line treatment for endometriosis-related pain: 13 of the marketed products fall in this category, though only some have received approval specifically for endometriosis, such as norethindrone and dienogest

Emerging evidence indicates that dependence can be shaped by metastatic niche, antioxidant nutrient availability and tumor genotype (for example, NRF2/KEAP1 signaling, baseline GPX4 expression and lipid composition)

Microchim Acta 187 , 38 (2020)

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For instance, berberine, a natural compound, downregulates the expression of SLC1A5 in Hep3B and BEL-7404 cells, inhibiting Gln uptake and consequently suppressing expansion of liver cancer cells and tumor progression in vivo (77)